Antileukemic action of buthionine sulfoximine: evidence for an intrinsic death mechanism based on oxidative stress
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چکیده
منابع مشابه
Potent Antileukemic Action of Naphthoquinoidal Compounds: Evidence for an Intrinsic Death Mechanism based on Oxidative Stress and Inhibition of DNA Repair
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15 صفحه اولButhionine sulfoximine diverts the melanogenesis pathway toward
23 Buthionine sulfoximine (BSO) is a specific inhibitor of γ-glutamylcysteine synthetase, thus 24 blocking the synthesis of glutathione (GSH). It is known that this makes that BSO affects melanin 25 synthesis because of the role of thiols in melanogenesis. However, BSO may also react with the 26 intermediate oxidation products of melanogenesis, a possibility that has not been investigated from ...
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ژورنال
عنوان ژورنال: Leukemia
سال: 1998
ISSN: 0887-6924,1476-5551
DOI: 10.1038/sj.leu.2401138